Society for Economic Botany/BSA Economic Botany Section
Gyllenhaal, Charlotte , Kadushin, Marian , waller, donald , Soejarto, Dr. Djaja D. .
Ethnobotanical versus random plant collections in natural product drug discovery.
Natural product drug discovery encompasses the search for new medications from plants and other natural sources. Discussion is ongoing as to proper sourcing of plant materials to optimize the yield of new medications or of new phytochemical compounds that may serve as leads for pharmaceutical drug development. Two primary approaches in use to acquire plant samples for discovery are the ethnobotanical and the random approaches. In a project to discover new bioactive compounds from plants of Vietnam and Laos (1998-2008) we used both approaches. Under a cooperative agreement, plants were acquired, on one side, through traditional medicine use from healers throughout Laos, and from villages surrounding a national park in Vietnam (the ethnobotanical collection pool). On the other side, plants were acquired using the random collection method from the forests of Cuc Phuong National Park, Ninh Binh Province, Vietnam (the random collection pool). All plants were extracted in Laos and Vietnam, respectively, and the extracts sent to the University of Illinois at Chicago and other cooperating laboratories for testing in a variety of cancer cell lines, HIV, malaria, tuberculosis and cancer chemoprevention. Botanical identification, ethnobotanical information and laboratory results were managed in a comprehensive database, the Natural Products Information System (NAPIS, White Point Systems). Chi-square analysis was used to test the hypothesis that plants used in traditional medicine were more likely to test positively in the various bioassays, and that plants with uses related to specific bioassays were more likely to test positively in the related bioassay. Results will be presented for the individual bioassays and all bioassays analyzed together.
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1 - University of Illinois at Chicago, Department of Medicinal Chemistry and Pharmacognosy, 539 Pharmacy, mc 781, 833 South Wood Street, Chicago, IL, 60612, USA
2 - University of Illinois at Chicago, Department of Biopharmaceutical Sciences, 335 Pharmacy, MC 865, 833 South Wood Street, Chicago, IL, 60612, USA
3 - College of Pharmacy, University of Illinois at Chicago, Chicago, Department of Medicinal Chemistry and Pharmacognosy, 833 S. Wood St., Chicago, IL, 60612, USA
International Collaborative Biodiversity Group.
Presentation Type: Oral Paper:Papers for Sections
Location: Maryland Room/Chase Park Plaza
Date: Monday, July 11th, 2011
Time: 8:00 AM